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Derivation of cellular survival kinetic parameters for experimental fractionated irradiation of rat skin. [X rays]

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3574776· OSTI ID:6380599
 [1];
  1. Michael Reese Medical Center, Chicago, IL
+ Show Author Affiliations
If different fractionation schedules yield similar normal tissue reactions in a given system, it may be assumed that the degree of cellular depletion in the irradiated tissues wil be about equal in each instance. On this basis, cell population kinetic parameters (mean cellular lethal dose, extrapolation number, slope ratio, regeneration rate, and repopulation limit) can be derived statistically from experimental or clinical data using a cellular lethality model designed to simulate a course of fractionated radiation therapy. Reactions following fractionated irradiation of the feet of rats were analyzed using this model and a computer search program designed for analysis of clinical data. A variety of fractionation schedules and levels of intensity in the radiation reaction of rat skin were analyzed. The parameters derived were internally consistent and were in agreement with known radiobiological parameters for rodent skin and other mammalian normal tissues. Different intensities of the skin reaction were associated with different levels of cellular depletion ranging from a log (surviving fraction) of -3 for moderate erythema to -8 for severe moist desquamation.
OSTI ID:
6380599
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 76:2; ISSN RAREA
Country of Publication:
United States
Language:
English

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Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CELL KILLING
COMPARATIVE EVALUATIONS
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
FRACTIONATED IRRADIATION
IONIZING RADIATIONS
IRRADIATION
IRRADIATION PROCEDURES
LIMBS
LOCAL IRRADIATION
MAMMALS
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RATS
RODENTS
SKIN
VERTEBRATES
X RADIATION