Combination Adriamycin and radiation therapy in gynecologic cancers

Journal Article · Sun Dec 01 04:00:00 EST 1974 · Gynecol. Oncol.; (United States)

DOI:https://doi.org/10.1016/0090-8258(74)90062-6· OSTI ID:7304930

Watring, W G; Byfield, J E; Lagasse, L D; Lee, Y D; Juillard, G; Jacobs, M; Smith, M L

Anthracyclic antibiotics, of which adriamycin is representative, have the ability to bind to cellular DNA and thereby interfere with the X ray repair process. When radiation survival curves of tissue cultures were studied, increased cell-killing was noted in those cultures with adriamycin over those without the drug. The mechanism by which this occurs may be related to a reduced rate of DNA strand break rejoining, as demonstrated by use of alkaline sucrose gradient techniques. A preliminary clinical Phase I study, in which patients with advanced gynecologic malignancy were treated by simultaneous adriamycin and X radiation, suggests that combined therapy is well-tolerated, and that such combinations may prove useful in selected patients.

• Research Organization: Univ. of California, Los Angeles
• OSTI ID: 7304930
• Journal Information: Gynecol. Oncol.; (United States), Journal Name: Gynecol. Oncol.; (United States) Vol. 2:4; ISSN GYNOA
• Country of Publication: United States
• Language: English

Related Subjects

560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTIBIOTICS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
DISEASES
DNA
DRUGS
INHIBITION
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PATIENTS
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOTHERAPY
RECOVERY
REPAIR
STRAND BREAKS
THERAPY