Relative radioresistance of xenogeneic and hybrid resistance to bone marrow transplantation. [Mice, gamma radiation]

Journal Article · Tue Feb 01 04:00:00 EST 1977 · Transplantation; (United States)

OSTI ID:7304908

Rauchwerger, J M; Gallagher, M T; Monie, H J; Trentin, J J

Following a single exposure to 1,100 R whole-body irradiation, (C57Bl/6 x A)F/sub 1/ hybrid mice were genetically resistant to transplantation of 5 x 10/sup 5/ C57 parental bone marrow cells (hybrid resistance). Hybrid resistance was minimally broken by increasing the radiation exposure to 2,200 R, and maximally broken by increasing it to 5,000 R. Following 1,100 R, (C57Bl/6 x A)F/sub 1/ hybrid mice were genetically resistant to transplantation of 5 x 10/sup 6/ Lewis RBM cells (xenogeneic resistance). This xenogeneic resistance was not even minimally broken following 5,000 R, but was broken following 6,600 R. With different doses of parental or xenogeneic marrow cells, it was found that the amount of irradiation exposure required to break either hybrid resistance or xenogeneic resistance was inversely proportional to the dose of bone marrow cells used.

• Research Organization: Baylor Coll. of Medicine, Houston, TX
• OSTI ID: 7304908
• Journal Information: Transplantation; (United States), Journal Name: Transplantation; (United States) Vol. 23:2; ISSN TRPLA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BONE MARROW
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
GAMMA RADIATION
HEMATOPOIETIC SYSTEM
HYBRIDIZATION
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MICE
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY
RODENTS
TISSUES
TRANSPLANTS
VERTEBRATES
WHOLE-BODY IRRADIATION