ANTIGENS RESPONSIBLE FOR BONE MARROW TRANSPLANTATION IMMUNITY

Journal Article · Wed Oct 01 04:00:00 EDT 1958 · Annals of the New York Academy of Sciences (U.S.)

DOI:https://doi.org/10.1111/j.1749-6632.1959.tb40853.x· OSTI ID:4281247

Makinodan, T; Gengozian, N; Albright, J F

The antigens responsible for the bone marrow transplantation immunity were determined by sensitizing the mice 2 or 6 weeks prior to the 950 r and rat bone marrow transplantation (950 r-RBM). Indicative of the sensitizing antigens was the increased mortality 15 and 30 days after 950 r-RBM in comparison to the nonsensitized 950 r-RBM mice. Sensitizing antigens were absent in the serum and red blood cells, but present in nucleated cells. They were localized in the nucleus, mitochondria, and microsomes in a reasonable concentration and in the supernatant fraction in a relatively low concentration. The antigens of the mitochondria and microsomes were resistant to nuclease and protease treatment. The nuclear antigens were resistant to ribonuclease and papain treatment, and slightly susceptible to trypsin. The antigenicity of desoxyribonucleasetreated nuclei was variable. (auth)

• Research Organization: Oak Ridge National Lab., Tenn.
• Sponsoring Organization: USDOE
• NSA Number: NSA-13-007382
• OSTI ID: 4281247
• Journal Information: Annals of the New York Academy of Sciences (U.S.), Journal Name: Annals of the New York Academy of Sciences (U.S.) Vol. Vol: 73; ISSN ANYAA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANTIGENS
BIOLOGY AND MEDICINE
BLOOD SERUM
BONE MARROW
CYTOLOGY
DNA-ASE
ENZYMES
ERYTHROCYTES
IMMUNITY
MICE
PAPAIN
RATS
RIBONUCLEIC ACID
RNA-ASE
SURVIVAL TIME
TRANSPLANTS
TRYPSIN