Histological changes in x-radiated salivary glands of the rhesus monkey

Thesis/Dissertation · Thu Jan 01 04:00:00 EST 1976

OSTI ID:7300318

Bowers, Jr, D E

Two groups of young female rhesus monkeys received fractionated doses of orthovoltage irradiation to their submandibular and sublingual glands respectively. The total dose was 4,950 roentgens given over a 15 day period. After from 10 days to two months, the animals were sacrificed and their glands processed for light and electron microscopy. At 10 days postirradiation the submandibular glands are composed of atrophied degranulated serous cells and mucous cells that are normal in appearance. The serous cells contain dilated endoplasmic reticulum, some secretory granule remnants and pale nuclei. The epithelial cells of the ducts contain numerous perinuclear lysosomal-like structures. The 20 and 30 day submandibular glands demonstrate a progressive atrophy of acinar cells including the mucous cells. The serous cells form cords, clumps and rosettes, while the mucous cells are pale staining and vacuolated. Many cells are binucleate and have pleomorphic nuclei. The acinar cells, as the ductal cells, contain cytolytic bodies. The 30 day glands show some evidence of repair as there are cells which contain secretory granules, Golgi apparatus and normal rough endoplasmic reticulum. Such cells are not seen in the 10 and 20 day glands. There is a slight increase of connective tissue in the irradiated submandibular glands and some evidence of the beginning of a chronic inflammatory reaction in the 30 day animals. No acute inflammation or necrosis was present in the submandibular glands.

• OSTI ID: 7300318
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ATROPHY
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DISEASES
ELECTROMAGNETIC RADIATION
ELECTRON MICROSCOPY
FRACTIONATED IRRADIATION
GLANDS
HISTOLOGY
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MICROSCOPY
MONKEYS
ORGANS
PATHOLOGICAL CHANGES
PRIMATES
RADIATION EFFECTS
RADIATIONS
SALIVARY GLANDS
VERTEBRATES
X RADIATION