Circular dimers of lambda DNA in infected, nonlysogenic Escherichia coli
Journal Article
·
· Virology; (United States)
Covalently closed circular dimerss of phage lambda DNA have been found in Escherichia coli infected with lambda. These dimers can be formed by either the lambda Red or Int systems, by a nonrecombinational replicative mechanism requiring the activity of the lambda O and P genes or by joining of the cohesive ends. Dimers mediated by the E. coli Rec system have not been observed. Those formed by the Int system often result from recombination between different DNA molecules; however, the Red-mediated dimer may be a result of replicative extension of a single DNA molecule. Trimers have also been observed but studied only briefly.
- Research Organization:
- Brandeis Univ., Waltham, MA
- OSTI ID:
- 7298147
- Journal Information:
- Virology; (United States), Journal Name: Virology; (United States) Vol. 81:2; ISSN VIRLA
- Country of Publication:
- United States
- Language:
- English
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