Effects of indomethacin on long-wave ultraviolet-induced delayed erythema

Journal Article · Tue Mar 01 04:00:00 EST 1977 · J. Invest. Dermatol.; (United States)

DOI:https://doi.org/10.1111/1523-1747.ep12492445· OSTI ID:7291087

Morison, W L; Paul, B S; Parrish, J A

Indomethacin, a known inhibitor of prostaglandin synthesis, administered topically as a 2.5% solution, intradermally in 10 mug doses, and orally in a dose of 150 mg/day for 2 days did not diminish the delayed erythema produced by long-wave ultraviolet light (320 to 400 nm). The delayed phototoxic erythema produced by 8-methoxypsoralen and subsequent exposure to the long-wave ultraviolet light was similarly unaffected. By comparison, topical and intradermal indomethacin treatment produced sustained decrease in the erythemal response to ultraviolet radiation in the UVB ranges (290 to 320 nm).

• Research Organization: Harvard Medical School, Boston
• OSTI ID: 7291087
• Journal Information: J. Invest. Dermatol.; (United States), Journal Name: J. Invest. Dermatol.; (United States) Vol. 68:3; ISSN JIDEA
• Country of Publication: United States
• Language: English

Related Subjects

560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DELAYED RADIATION EFFECTS
DRUGS
ELECTROMAGNETIC RADIATION
ERYTHEMA
IRRADIATION
MAMMALS
MAN
ORGANS
PRIMATES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
SKIN
SYMPTOMS
ULTRAVIOLET RADIATION
VERTEBRATES