Anti-inflammatory and pharmacological effects of topically applied flurbiprofen on human skin 24 hours after ultraviolet B irradiation
Human abdominal skin was irradiated, with three minimal erythema doses of ultraviolet B (290 to 320 nm) radiation, producing maximal erythema at 24h, with an associated rise in PGE2 and PGF2 alpha, measured by gas chromatograph-mass spectrometry. Topical applications of 5% flurbiprofen, a prostaglandin synthetase inhibiting drug applied immediately after irradiation, partially suppressed the uvB evoked erythema at 24 h but totally prevented elevation of PGE2 and PGF2 alpha, without any associated significant rise in arachidonic acid. These findings support the view that erythema due to uvB is only partly mediated by products of cyclo-oxygenase pathway, and should prompt a search for other mediators, including non-prostaglandin metabolites of arachidonic acid.
- OSTI ID:
- 6269472
- Journal Information:
- Prostaglandins; (United States), Journal Name: Prostaglandins; (United States) Vol. 5:5; ISSN PRGLB
- Country of Publication:
- United States
- Language:
- English
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560400* -- Other Environmental Pollutant Effects
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ARACHIDONIC ACID
BIOLOGICAL EFFECTS
BODY
CARBOXYLIC ACIDS
DRUGS
ELECTROMAGNETIC RADIATION
ENZYMES
ERYTHEMA
ETIOLOGY
LIGASES
MONOCARBOXYLIC ACIDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
POST-IRRADIATION THERAPY
PROSTAGLANDINS
RADIATIONS
SKIN
SYMPTOMS
THERAPY
ULTRAVIOLET RADIATION