Prostaglandins can modify gamma-radiation and chemical induced cytotoxicity and genetic damage in vitro and in vivo

Journal Article · Thu Nov 30 23:00:00 EST 1989 · Prostaglandins; (USA)

DOI:https://doi.org/10.1016/0090-6980(89)90050-6· OSTI ID:7006540

Das, U N; Ramadevi, G; Rao, K P; Rao, M S ^[1]

---

1. Nizam's Institute of Medical Sciences, Hyderabad (India)

The effect of prostaglandin E1, E2, and F2 alpha on gamma-radiation, benzo(a)pyrene and diphenylhydantoin-induced cytotoxicity in vivo and genotoxicity in vitro was investigated. Prostaglandin E1 prevented both cytotoxic and genotoxic actions of all the three agents, where as both PGE2 and PGF2 alpha were ineffective. In fact, it was seen that both PGE2 and PGF2 alpha are genotoxic by themselves. Gamma-linolenic acid and dihomogamma-linolenic acid, the precursor of PGE1 were also as protective as that of PGE1, where as arachidonic acid, the precursor of 2 series PGs, has genotoxic actions to human lymphocytes in vitro. These results suggest that prostaglandins and their precursors can determine the susceptibility of cells to cytotoxic and genotoxic actions of chemicals and radiation. This study is particularly interesting since, it is known that some tumor cells contain excess of PGE2 and PGF2 alpha and many carcinogens can augment the synthesis of 2 series of PGs.

• OSTI ID: 7006540
• Journal Information: Prostaglandins; (USA), Journal Name: Prostaglandins; (USA) Vol. 38:6; ISSN PRGLB; ISSN 0090-6980
• Country of Publication: United States
• Language: English

Related Subjects

560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
560300 -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
AROMATICS
BENZOPYRENE
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE MARROW
CHROMOSOMAL ABERRATIONS
CONDENSED AROMATICS
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
HEMATOPOIETIC SYSTEM
HYDROCARBONS
IONIZING RADIATIONS
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MAN
MATERIALS
MICE
MUTATIONS
ORGANIC COMPOUNDS
ORGANS
PRECURSOR
PRIMATES
PROSTAGLANDINS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RODENTS
SISTER CHROMATID EXCHANGES
SOMATIC CELLS
TISSUES
TOXICITY
VERTEBRATES