Influence of some prostaglandins on DNA synthesis and DNA excision repair in mouse spleen cells in vitro
Journal Article
·
· Prostaglandins; (United States)
OSTI ID:5733512
In vitro experiments were performed on mouse spleen cells to establish possible influences of some naturally occurring prostaglandins on DNA synthesis and DNA excision repair. The prostaglandins A1, B1, E1, E2, and F2 alpha were tested in concentrations of lopg, 5 ng and 2.5 microgram per ml cell suspension. DNA synthesis was significantly increased by PgF2 alpha in all the three concentrations tested, while the other tested prostaglandins were essentially ineffective. DNA excision repair was significantly inhibited by PgE1 and PgE2 at 5 ng/ml and at 2.5 microgram/ml but increased by PgF2 alpha in the two lower concentrations. The rejoining of DNA-strand breaks after gamma-irradiation was slightly reduced by PgE1, PgE2 and PgF2 alpha at 2.5 microgram/ml.
- Research Organization:
- Univ., Innsbruck, Austria
- OSTI ID:
- 5733512
- Journal Information:
- Prostaglandins; (United States), Journal Name: Prostaglandins; (United States) Vol. 15:3; ISSN PRGLB
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560111 -- Radiation Effects on Biochemicals-- In Vitro-- (-1987)
560114* -- Radiation Effects on Biochemicals-- In Animals-- (-1987)
560121 -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BODY
CELL CULTURES
DNA
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
IN VITRO
IONIZING RADIATIONS
MAMMALS
MICE
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PROSTAGLANDINS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RECOVERY
REPAIR
RODENTS
SPLEEN
STRAND BREAKS
VERTEBRATES
560114* -- Radiation Effects on Biochemicals-- In Animals-- (-1987)
560121 -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BODY
CELL CULTURES
DNA
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
IN VITRO
IONIZING RADIATIONS
MAMMALS
MICE
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PROSTAGLANDINS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RECOVERY
REPAIR
RODENTS
SPLEEN
STRAND BREAKS
VERTEBRATES