Influence of age on whole-body retention and distribution of /sup 115m/Cd in the rat

Journal Article · Sat Jan 01 04:00:00 EST 1977 · Environ. Res.; (United States)

OSTI ID:7286901

Kello, D; Kostial, K

The influence of age on whole-body retention and organ distribution of intraperitoneally applied /sup 115//sup m/CdCl/sub 2/ was studied in 1-, 3-, 6-, and 52-week-old rats. The mean percent values of /sup 115//sup m/Cd retention in the whole body decreased with increasing age. The distribution of /sup 115//sup m/Cd in the body on the 14th day after application shows that in all age groups most of the cadmium is accumulated in the liver (45 to 56 percent) and kidneys (4 to 6 percent). In younger rats the percentage of cadmium in the kidney and blood was always higher than in older animals in contrast to the liver where it was lower. The percentage of the dose in the liver, kidneys, and blood represents however, a considerably lower fraction of the total whole-body retention in younger animals than in older rats. It is therefore concluded that age bears a significant influence on cadmium metabolism. This might be important for estimating cadmium body burden and critical organ exposure in the youngest age group.

• Research Organization: Inst. for Medical Research and Occupational Health, Zagreb
• OSTI ID: 7286901
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 14:1; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE DEPENDENCE
AGE GROUPS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL ACCUMULATION
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
CADMIUM 115
CADMIUM CHLORIDES
CADMIUM COMPOUNDS
CADMIUM HALIDES
CADMIUM ISOTOPES
CHLORIDES
CHLORINE COMPOUNDS
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
DOSE-RESPONSE RELATIONSHIPS
ECOLOGICAL CONCENTRATION
ELEMENTS
EVEN-ODD NUCLEI
GLANDS
HALIDES
HALOGEN COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOTOPES
KIDNEYS
LIVER
MAMMALS
METABOLISM
METALS
NUCLEI
ORGANS
RADIOISOTOPES
RADIONUCLIDE KINETICS
RATS
RODENTS
TISSUE DISTRIBUTION
TRACE AMOUNTS
VERTEBRATES