Bone marrow /sup 99m/Tc sulfur colloid distribution and marrow cellularity

Journal Article · Wed Jan 01 00:00:00 EST 1975 · Am. J. Med. Sci.; (United States)

DOI:https://doi.org/10.1097/00000441-197511000-00002· OSTI ID:7286144

Henry, R E; Fletcher, J W; George, E A; Donati, R M

The relationship between marrow distribution as imaged with /sup 99m/Tc sulfur colloid and histologic estimate of bone marrow cellularity was examined in 101 patients. The patients were divided into three groups according to marrow cellularity: normocellular, hyperellular or hypocellular marrow. The marrow distribution of these patients was graded as extended, not extended or not visualized. A general association between marrow cellularity and marrow distribution was found. Seventy-seven percent of patients with normocellular marrow had limitation of marrow within normal sites and a similar number of patients with reactive hypercellular marrow had marrow extension. On analysis of the patients that were exceptions to this generalization the following observations were made. In patients in whom the marrow is hypercellular and infiltrated with abnormal cells or tissue the marrow distribution may not be visualized with radiocolloid. Stimulation of hematopoiesis may result in marrow hypercellularity without marrow extension beyond the usual sites. Stimulation of one or more hematopoietic cell lines may result in marrow extension without marrow hypercellularity, suggesting an impariment of hematopoietic cell response. Peripheral marrow extension as observed with radiocolloid, therefore, is not simply a reflection of marrow hypercellularity but probably represents a response to the bone marrow stroma to situations in which one or more hematopoietic cell lines is stimulated. (auth)

• Research Organization: St. Louis Veterans Administration Hospital
• OSTI ID: 7286144
• Journal Information: Am. J. Med. Sci.; (United States), Vol. 270:3
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
BONE MARROW
IMAGES
BONE MARROW CELLS
DISTRIBUTION
BLOOD FORMATION
COLLOIDS
PATIENTS
SULFUR
TECHNETIUM 99
TRACER TECHNIQUES
ANIMAL CELLS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CONNECTIVE TISSUE CELLS
DISPERSIONS
ELEMENTS
HEMATOPOIETIC SYSTEM
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
NONMETALS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPES
SOMATIC CELLS
TECHNETIUM ISOTOPES
TISSUES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550800 - Morphology