Prevalence of symptoms of systemic lupus erythematosus (SLE) and of fluorescent antinuclear antibodies associated with chronic exposure to trichloroethylene and other chemicals in well water
- Univ. of Southern California, Los Angeles (United States)
Criteria for the recognition of systemic lupus erythematosus (SLE) were applied to 362 subjects exposed to trichloroethylene, trichloroethane, inorganic chromium, and other chemicals in water obtained from wells in an industrially contaminated aquifer in Tucson, Arizona. Their antinuclear autoantibodies were measured by fluorescence (FANA) in serum. Ten patients with clinical SLE and/or other collagen-vascular diseases were considered separately. Results were compared to an Arizona control group, to published series, and to laboratory controls. Frequencies of each of 10 ARA symptoms were higher in exposed subjects than in any comparison group except those with clinical SLE. The number of subjects with 4 or more symptoms was 2.3 times higher compared to referent women and men. FANA titers > 1:80 was approximately 2.3 times higher in women but equally frequent in men as in laboratory controls. ARA score and FANA rank were correlated with a coefficient (cc) of .1251, r{sup 2} = .0205 in women and this correlation was almost statistically significant in men cc = .1282, r{sup 2} = .0253. In control men and women neither correlation was significant. Long-term low-dose exposure to TCE and other chemicals in contaminated well water significantly increased symptoms of lupus erthematosus as perceived by the ARA score and the increased FANA titers.
- OSTI ID:
- 7279437
- Journal Information:
- Environmental Research; (United States), Vol. 57:1; ISSN 0013-9351
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ARIZONA
WATER POLLUTION
CHLORINATED ALIPHATIC HYDROCARBONS
TOXICITY
CHROMIUM
LUPUS
EPIDEMIOLOGY
WATER WELLS
CONTAMINATION
ANTIBODIES
CHRONIC EXPOSURE
FLUORESCENCE
MAN
SYMPTOMS
VASCULAR DISEASES
ANIMALS
DEVELOPED COUNTRIES
DISEASES
ELEMENTS
FEDERAL REGION IX
HALOGENATED ALIPHATIC HYDROCARBONS
IMMUNE SYSTEM DISEASES
LUMINESCENCE
MAMMALS
METALS
NORTH AMERICA
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
POLLUTION
PRIMATES
TRANSITION ELEMENTS
USA
VERTEBRATES
WELLS
540320* - Environment
Aquatic- Chemicals Monitoring & Transport- (1990-)
560300 - Chemicals Metabolism & Toxicology