In vivo mutagenicity and clastogenicity of ionizing radiation in nuclear medicine
The overall goal of our research remains to investigate the mutagenic and clastogenic effects of exposure to low levels of ionizing radiation to human lymphocytes. Principally, we are studying hospital patients referred to a nuclear medicine department for diagnostic cardiac imaging and nuclear medicine technologies who administer radionuclides. Emphasis in the first year, as described in the first progress report, was on optimization of the hprt mutation assay, measurement of mutant frequencies in patients imaged with thallium-201, and measurement of mutant frequencies in controls. Emphasis in the second year has been on measurements of (1) chromosome aberrations in patients imaged with thallium-201, (2) mutant frequencies in patients imaged with technetium-99, (3) mutant frequencies in nuclear medicine technicians and physical therapists, (4) mutant frequencies in patients treated for Hodgkins disease with radiotherapy. The progress in these areas is described.
- Research Organization:
- Harvard Univ., Boston, MA (United States). School of Public Health
- Sponsoring Organization:
- USDOE; USDOE, Washington, DC (United States)
- DOE Contract Number:
- FG02-89ER60745
- OSTI ID:
- 7278966
- Report Number(s):
- DOE/ER/60745-T2; ON: DE92016651
- Country of Publication:
- United States
- Language:
- English
Similar Records
In vivo mutagenicity and clastogenicity of ionizing radiation in nuclear medicine
In vivo mutagenicity and clastogenicity of ionizing radiation in nuclear medicine. Final performance report, January 1, 1989--December 31, 1991
Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
LYMPHOCYTES
BIOLOGICAL RADIATION EFFECTS
MAN
CORRELATIONS
IONIZING RADIATIONS
MUTATIONS
NUCLEAR MEDICINE
OCCUPATIONAL EXPOSURE
PATIENTS
PERSONNEL
PROGRESS REPORT
TECHNETIUM 99
THALLIUM 201
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DAYS LIVING RADIOISOTOPES
DOCUMENT TYPES
ELECTRON CAPTURE RADIOISOTOPES
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LEUKOCYTES
MAMMALS
MATERIALS
MEDICINE
NUCLEI
ODD-EVEN NUCLEI
PRIMATES
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
SECONDS LIVING RADIOISOTOPES
SOMATIC CELLS
TECHNETIUM ISOTOPES
THALLIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOI
560151* - Radiation Effects on Animals- Man
550601 - Medicine- Unsealed Radionuclides in Diagnostics
560120 - Radiation Effects on Biochemicals
Cells
& Tissue Culture