In vivo mutagenicity and clastogenicity of ionizing radiation in nuclear medicine. Final performance report, January 1, 1989--December 31, 1991

Technical Report · Tue Dec 31 00:00:00 EST 1991

DOI:https://doi.org/10.2172/10136280· OSTI ID:10136280

Kelsey, K T

The overall goal of our research was to investigate the mutagenic and clastogenic effects of exposure to low levels of ionizing radiation to human lymphocytes. Principally, we studied hospital patients referred to a nuclear medicine department for diagnostic cardiac imaging and nuclear medicine technologists who administer radionuclides. Emphasis in the first year, as described in the first progress report, was on optimization of the hprt mutation assay, measurement of mutant frequencies in patients imaged with thallium-201, and measurement of mutant frequencies in controls. Emphasis in the second and third years was on measurements of: (1) chromosome aberrations in patients imaged with thallium-201; (2) mutant frequencies in patients imaged with technetium-99; (3) mutant frequencies in nuclear medicine technicians and physical therapists; and (4) mutant frequencies in patients treated for Hodgkins disease with radiotherapy. The completed work has been published and is described below in more detail.

• Research Organization: Harvard Univ., Boston, MA (United States). School of Public Health
• Sponsoring Organization: USDOE, Washington, DC (United States)
• DOE Contract Number: FG02-89ER60745
• OSTI ID: 10136280
• Report Number(s): DOE/ER/60745-4; ON: DE92011571
• Resource Relation: Other Information: PBD: [1991]
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
HUMAN POPULATIONS
GENETIC RADIATION EFFECTS
PROGRESS REPORT
MUTAGENESIS
IN VIVO
IONIZING RADIATIONS
CHROMOSOMAL ABERRATIONS
THALLIUM 201
TECHNETIUM 99
560120
550400
RADIATION EFFECTS ON BIOCHEMICALS, CELLS, AND TISSUE CULTURE
GENETICS