In vitro interaction of selected phospholipid species with mercuric chloride using Fourier transform sup 1 H-NMR

Journal Article · Sun Sep 01 00:00:00 EDT 1991 · Bulletin of Environmental Contamination and Toxicology; (United States)

DOI:https://doi.org/10.1007/BF01702193· OSTI ID:7278761

Shinada, Masayuki; Muto, Hajime; Takizawa, Yukio ^[1]

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1. Akita Univ. (Japan)

Many studies on the mercury toxicities have been accumulated since the outbreak of Minamata Disease.' There have been few reports on the reaction mechanisms of mercurials with phospholipids which substantially locate in biological membranes, although the interactions of nucleotides or nucleosides with mercurials have been reported. Recently, the study on the interaction of mercuric chloride (HgCl{sub 2}) with amino polar heads of model membranes containing phosphatidylserine (PS) and phosphatidylethanolamine (PE) has been reported, as the results from the fluorescence polarization analysis using 1,6-diphenyl-1,3,5-hexatriene. The authors demonstrate here the interactions of dioleoylphosphatidylethanolamine (DOPE) and dioleoylphosphatidylcholine (DOPC) with HgCl{sub 2}, using Fourier transform {sup 1}H-NMR ({sup 1}H-FT-NMR).

• OSTI ID: 7278761
• Journal Information: Bulletin of Environmental Contamination and Toxicology; (United States), Vol. 47:3; ISSN 0007-4861
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
MERCURY CHLORIDES
NUCLEAR MAGNETIC RESONANCE
PHOSPHOLIPIDS
CHEMICAL SHIFT
FLUORESCENCE
FOURIER TRANSFORM SPECTROMETERS
NUCLEOTIDES
PROTONS
BARYONS
CHLORIDES
CHLORINE COMPOUNDS
ELEMENTARY PARTICLES
ESTERS
FERMIONS
HADRONS
HALIDES
HALOGEN COMPOUNDS
LIPIDS
LUMINESCENCE
MAGNETIC RESONANCE
MEASURING INSTRUMENTS
MERCURY COMPOUNDS
MERCURY HALIDES
NUCLEONS
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
RESONANCE
SPECTROMETERS
560300* - Chemicals Metabolism & Toxicology