Methoxyethanol biotransformation by liver and testis of rats is modulated by phenobarbital pretreatment

Conference · Wed Feb 26 04:00:00 EST 1992 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:7278647

Kaphalia, L; Au, W; Moslen, M T ^[1]

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1. Univ. of Texas, Galveston (United States)

Toxicity of 2-methoxyethanol (ME), a widely used solvent, is known to be dependent on its biotransformation by alcohol dehydrogenase to methoxyacetaldehyde (MA) and then by aldehyde dehydrogenase to methoxyacetic acid (MAA). However, little is known about the effects of enzyme inducers on the biotransformation of ME by liver or target organs such as the testis. The authors objective was to examine effects of phenobarbital pretreatment of Sprague Dawley rats on hepatic and testicular biotransformation of ME {r arrow} MA and MA {r arrow} MAA. Phenobarbital diminished hepatic ME {r arrow} MA activity by 80% when activity was calculated per mg prot and by 50% per liver/kg body weight. Hepatic MA {r arrow} MA activity was increased 25% by phenobarbital without an appreciable change in testicular MA {r arrow} MAA activity. Further studies are needed to determine if these effects of phenobarbital pretreatment on tissue biotransformation of ME and MA are associated with changes in the kinetics or toxicity of this solvent.

• OSTI ID: 7278647
• Report Number(s): CONF-9204141--
• Conference Information: Journal Name: FASEB Journal (Federation of American Societies for Experimental Biology); (United States) Journal Volume: 6:4
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANESTHETICS
ANIMALS
ANTICONVULSANTS
AZINES
BARBITURATES
BIOLOGICAL EFFECTS
BODY
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DIGESTIVE SYSTEM
DRUGS
ENZYME ACTIVITY
ENZYMES
GLANDS
GONADS
HETEROCYCLIC COMPOUNDS
HYPNOTICS AND SEDATIVES
LIVER
MALE GENITALS
MAMMALS
METABOLISM
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANIC SOLVENTS
ORGANS
OXIDOREDUCTASES
PHENOBARBITAL
PROTEINS
PYRIMIDINES
RATS
RODENTS
SOLVENTS
TESTES
TOXICITY
VERTEBRATES