Interaction of cadmium with hepatic and testicular microsomal enzymes

Thesis/Dissertation · Fri Jan 01 04:00:00 EST 1982

OSTI ID:6271576

Wetzel, L T

Cadmium, a ubiquitous environmental pollutant, inhibits or activates a number of microsomal enzymes. Among the enzymes affected by cadmium are cytochrome P-450 containing mixed-function oxidases (MFO) which are present in both the liver and testis. Cadmium affects MFO activity, and as a result, cadmium-induced alterations in BP metabolism might alter BP toxicity in the liver or testis. In addition, MFO essential for testosterone production are located in the testis and cadmium-MFO interactions in the testis might alter androgen production. Therefore studies were carried out to evaluate the interaction of cadmium with heptic and testicular MFO. The results indicated that cadmium affected the activities of hepatic and testicular MFO and in so doing may influence the toxicity of BP and other chemicals in liver and testes. In addition, exposure to metals may also compromise testicular androgen biosynthesis.

• OSTI ID: 6271576
• Country of Publication: United States
• Language: English

Related Subjects

560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BODY
CADMIUM
CELL CONSTITUENTS
DIGESTIVE SYSTEM
ELEMENTS
ENZYME ACTIVITY
ENZYMES
GLANDS
GONADS
IN VITRO
LIVER
MALE GENITALS
METALS
MICROSOMES
MIXED-FUNCTION OXIDASES
ORGANOIDS
ORGANS
OXIDOREDUCTASES
OXYGENASES
TESTES