Relative renal accumulation of Tc-99m penicillamine as an index of differential renal function: concise communication
The relative renal accumulation of technetium-99m penicillamine (TPEN) was evaluated as an index of differential renal function. Using a scintillation camera interfaced to a computer, renal uptake of TPEN was determined for each kidney by subtracting the renal activity at 10 min from that at 25 min. This percentage of TPEN activity in the left kidney was compared with the percentage of total creatinine clearance contributed by the left kidney in six patients with ureteral obstruction and nephrostomy drainage. The two measurements agreed extremely well, with a correlation coefficient of 0.98. The relative renal uptake of TPEN and similar cortex imaging agents such as Tc-99m dimercaptosuccinic acid can probably be used to assess differential renal function.
- Research Organization:
- Veterans Administration Hospital, San Diego, CA
- OSTI ID:
- 7277115
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 19:2; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
AMINO ACIDS
AZOLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL ACCUMULATION
BODY
CAMERAS
CARBOXYLIC ACIDS
CHELATING AGENTS
COUNTING TECHNIQUES
CREATININE
DIAGNOSTIC TECHNIQUES
DRUGS
HETEROCYCLIC COMPOUNDS
HOURS LIVING RADIOISOTOPES
IMIDAZOLES
IMINES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KIDNEYS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PENICILLAMINE
PHYSIOLOGY
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RESPONSE MODIFYING FACTORS
SCINTISCANNING
TECHNETIUM 99
TECHNETIUM ISOTOPES
THIOLS
URETERS
URINARY TRACT
YEARS LIVING RADIOISOTOPES