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Acute radiation sickness amelioration analysis. Technical report, 20 July 1990-19 July 1993

Technical Report ·
OSTI ID:7272595
; ;

Three tasks were conducted under the Acute Radiation Sickness Amelioration Analysis in support of the Defense Nuclear Agency (DNA) and NATO Army Armaments Group (NAAG) Project Group 29 (PG-29) on drugs for the prevention of radiation-induced nausea and vomiting: (1) documents were collected and entered into a data base, (2) data reviews and analyses were performed, and (3) PG-29 and Triservice meetings involving anti-emetic drug development were supported and documented. Approximately 2000 documents were collected, with 1424 complete bibliographic citations entered into a WordPerfect 5.1 data base. Eight reviews and analyses addressing different aspects of the safety and efficacy of the candidate anti-emetic drugs ondansetron and granistron were prepared. Support was provided for seven international PG-29 meetings and two U.S. Triservice meetings in which the efforts of PG-29 were discussed. These tasks have enabled the DNA and PG-29 to make good progress toward the goal of recommending a serotonin type-3 (5-HT3) receptor antagonist anti-emetic drug for use in military personnel.

Research Organization:
Science Applications International Corp., McLean, VA (United States)
OSTI ID:
7272595
Report Number(s):
AD-A-279084/8/XAB; CNN: DNA001-90-C-0111
Country of Publication:
United States
Language:
English

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Related Subjects

560180* -- Radiation Protection Procedures-- (1992-)
61 RADIATION PROTECTION AND DOSIMETRY
AMINES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZAARENES
AZOLES
BIBLIOGRAPHIES
COMPILED DATA
DATA
DATA PROCESSING
DNA
DOCUMENT TYPES
DRUGS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INDOLES
INFORMATION
MAMMALS
MAN
MEMBRANE PROTEINS
MILITARY PERSONNEL
NAUSEA
NEUROREGULATORS
NUCLEIC ACIDS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PERSONNEL
PRIMATES
PROCESSING
PROGRESS REPORT
PROTEINS
PYRROLES
RADIATION PROTECTION
RADIOPROTECTIVE SUBSTANCES
RECEPTORS
RECOMMENDATIONS
SAFETY
SEROTONIN
SYMPATHOMIMETICS
SYMPTOMS
TASK SCHEDULING
TRYPTAMINES
VERTEBRATES
VOMITING