Is all radiation-induced emesis ameliorated by 5-HT3 receptor antagonists. (Reannouncement with new availability information)

Technical Report · Thu Dec 31 04:00:00 EST 1992

OSTI ID:177489

Rabin, B M; King, G L

Exposing ferrets to gamma rays or X-rays produces vomiting that can be attenuated by 5-HT3 receptor antagonists and by subdiaphragmatic vagotomy. The present experiments evaluated the effectiveness of these treatments on emesis evoked by exposure to other types of radiation, fast neutrons from a nuclear reactor and high-energy protons (200 MeV), which differ in the relative effectiveness with which they produce vomiting. The results indicated that higher doses of 5-HT3 receptor antagonists Eusatron (0.03 and 0.30 mg/kg, s.c.) and Ondansetron (0.10 and 0.30 mg/kg, s.c.) prevented emesis following neutron irradiation. Lower doses of these 5-HT3 receptor antagonists and subdiaphragmatic vagotomy attenuated neutron-induced emesis, increasing the latency and decreasing the severity of the emetic episodes. Ondansetron (0.50 and 1.00 mg/kg, s.c.) completely prevented vomiting following exposure to high-energy protons. The results are interpreted as indicating that similar 5-HT3-dependent mechanisms mediate emesis produced by exposure to different types of radiation, despite differences in their relative effectiveness.

• Research Organization: Armed Forces Radiobiology Research Inst., Bethesda, MD (United States)
• OSTI ID: 177489
• Report Number(s): AD-A--257407/7/XAB; AFRRI-SR--92-33
• Country of Publication: United States
• Language: English

Related Subjects

56 BIOLOGY AND MEDICINE
APPLIED STUDIES
BIOLOGICAL RADIATION EFFECTS
CATS
FAST NEUTRONS
IRRADIATION
PHARMACOLOGY
PROTONS
RADIOPROTECTIVE SUBSTANCES
RECEPTORS
TESTING
VOMITING