Endogenous mammary tumor viruses in mice. [X radiation]
Journal Article
·
· Cold Spring Harbor Symp. Quant. Biol.; (United States)
OSTI ID:7270322
The hypothesis of an endogenous mammary tumor virus seems to be substantiated in this paper by: transfer of genetic information for an MTV in vitro by GR sperm cells; segregation of MTV-P and MTV-L markers in the test cross of the F/sub 1/ hybrid between C3Hf, producing MTV-L, and GR, releasing MTV-P; induction of MTV antigens by BrdU in cultures of kidneys from various mouse strains; and induction of MTV-O in BALB/c mice by lethal doses of radiation. The picture that emerges is that different genetic systems control the expression of endogenous mammary tumor viruses. There are those which seem to affect only that germinal provirus with which they are genetically linked, while others have an influence on other germinal proviruses as well as somatic proviruses. Further studies on the genetic regulation of the expression of the germinal MTV proviruses are in progress.
- Research Organization:
- Radiobiological Inst. of the Organization for Health Research TNO, Rijswijk, Netherlands
- OSTI ID:
- 7270322
- Journal Information:
- Cold Spring Harbor Symp. Quant. Biol.; (United States), Journal Name: Cold Spring Harbor Symp. Quant. Biol.; (United States) Vol. 29:2; ISSN CSHSA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560131* -- Radiation Effects on Microorganisms-- Basic Studies-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTIMETABOLITES
ANTIMITOTIC DRUGS
AZINES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGY
BODY
BROMOURACILS
BUDR
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
GAMETES
GENETICS
GERM CELLS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IONIZING RADIATIONS
KIDNEYS
MAMMALS
MICE
MICROORGANISMS
NEOPLASMS
NUCLEOSIDES
NUCLEOTIDES
ONCOGENIC VIRUSES
ORGANIC BROMINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PARASITES
PYRIMIDINES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RIBOSIDES
RODENTS
SPERMATOZOA
URACILS
VERTEBRATES
VIRUSES
X RADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTIMETABOLITES
ANTIMITOTIC DRUGS
AZINES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGY
BODY
BROMOURACILS
BUDR
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
GAMETES
GENETICS
GERM CELLS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IONIZING RADIATIONS
KIDNEYS
MAMMALS
MICE
MICROORGANISMS
NEOPLASMS
NUCLEOSIDES
NUCLEOTIDES
ONCOGENIC VIRUSES
ORGANIC BROMINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PARASITES
PYRIMIDINES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RIBOSIDES
RODENTS
SPERMATOZOA
URACILS
VERTEBRATES
VIRUSES
X RADIATION