Latent and persistent lethal injury in mouse salivary gland cells following gamma irradiation
Journal Article
·
· Radiat. Res.; (United States)
Newly synthesized DNA in previously irradiated and isoproterenol-stimulated mouse salivary gland cells was found to be quickly degraded when the stimulation for DNA synthesis was given 10 days after a dose of 1000 rad ..gamma.. radiation. The degradation of the DNA was due to degeneration of acinar cells prior to mitosis. When the stimulation with isoproterenol was given 1 or 3 months after irradiation, DNA degradation in parotids was not detectable. An autoradiographic analysis revealed, however, that about half of the acinar cells labeled with tritiated thymidine were eliminated from irradiated parotids in a few days, even when the stimulation with isoproterenol was given 3 months after irradiation. This indicates that irradiation of mouse salivary gland cells produced latent lethal damage and that this damage is unmasked by the stimulation for DNA synthesis and cell division.
- Research Organization:
- Tohoku Univ., Sendai
- OSTI ID:
- 7267046
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 67:1; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AUTORADIOGRAPHY
AZINES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOSYNTHESIS
BODY
CELL DIVISION
DELAYED RADIATION EFFECTS
DNA
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
GAMMA RADIATION
GLANDS
HETEROCYCLIC COMPOUNDS
IONIZING RADIATIONS
IRRADIATION
LABELLED COMPOUNDS
MAMMALS
MICE
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PARTIAL BODY IRRADIATION
PYRIMIDINES
RADIATION EFFECTS
RADIATIONS
RIBOSIDES
RODENTS
SALIVARY GLANDS
SYNTHESIS
THYMIDINE
TRITIUM COMPOUNDS
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AUTORADIOGRAPHY
AZINES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOSYNTHESIS
BODY
CELL DIVISION
DELAYED RADIATION EFFECTS
DNA
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
GAMMA RADIATION
GLANDS
HETEROCYCLIC COMPOUNDS
IONIZING RADIATIONS
IRRADIATION
LABELLED COMPOUNDS
MAMMALS
MICE
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PARTIAL BODY IRRADIATION
PYRIMIDINES
RADIATION EFFECTS
RADIATIONS
RIBOSIDES
RODENTS
SALIVARY GLANDS
SYNTHESIS
THYMIDINE
TRITIUM COMPOUNDS
VERTEBRATES