Avian mixed function oxidases as a monitoring device

Conference · Thu Sep 01 00:00:00 EDT 1988 · Preprints of Papers Presented at National Meeting, Division of Water, Air and Waste Chemistry, American Chemical Society; (USA)

OSTI ID:7267014

Peakall, D B; Kennedy, S ^[1]

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1. National Wildlife Research Center, Ottawa, Ontario (Canada)

Mixed function oxidases enzymes (MFOs) are induced by a wide variety of compounds, both natural and xenobiotic, and play a central role in the detoxication process. The use of MFOs for the biological monitoring of contamination in aquatic systems has recently been reviewed. The authors concluded that the induction of these enzymes can fulfill the requirement of most sensitive biological responses for assessing a variety of organic pollution conditions. In this paper the use of MFOs for biological monitoring in birds is evaluated. There is considerable difficulty in comparing results in MFO activity among different groups. A wide variety of substrates and conditions have been employed. The hepatic MFO activity of the Sprague-Dawley rat can be used as a reference value for MFO work. It would be valuable if all groups used the rat as standard running it against the most widely used substrates (AHH, EROD, aldrin epoxidase). Vials from a pool of hepatic microsomal can be frozen and standards run with each run. This allows quality control to be maintained within the laboratory as well allowing a comparison to other laboratories.

• OSTI ID: 7267014
• Report Number(s): CONF-8909236-; CODEN: ACWCA
• Journal Information: Preprints of Papers Presented at National Meeting, Division of Water, Air and Waste Chemistry, American Chemical Society; (USA), Vol. 28:2; Conference: JAERI/EPA workshop on residual radiation and recycle criteria, St. Michaels, MD (USA), 27-28 Sep 1989; ISSN 0099-7293
• Country of Publication: United States
• Language: English

Related Subjects

54 ENVIRONMENTAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AQUATIC ECOSYSTEMS
CONTAMINATION
BIRDS
SENSITIVITY
MIXED-FUNCTION OXIDASES
ENZYME INDUCTION
WATER POLLUTION
BIOLOGICAL INDICATORS
XENOBIOTICS
TOXICITY
BIOLOGICAL ACCUMULATION
ANIMALS
ECOSYSTEMS
ENZYMES
GENE REGULATION
OXIDOREDUCTASES
OXYGENASES
POLLUTION
VERTEBRATES
540320* - Environment
Aquatic- Chemicals Monitoring & Transport- (1990-)
560300 - Chemicals Metabolism & Toxicology