Improving cancer treatment with cyclotron produced radionuclides
Our goal is to improve the scientific basis for tumor diagnosis, treatment and treatment follow-up based on the use of cyclotron produced radiotracers in oncology. The grant includes 3 interactive components: Radiochemistry/Cyclotron; Pharmacology; and Immunology. The radiochemistry group seeks to develop innovative cyclotron targetry, radiopharmaceuticals, and radiolabeled antibodies, which are then used to assess important unanswered questions in tumor pharmacology and immunology. Examples include selected positron emitting radionuclides, such as Iodine-124, and Ga-66; I-124, I-123, I-131 labeled iododeoxyuridine, C-11 colchicine, and antimetabolites, like C-11 methotrexate; and radiolabeled antibodies, 3F8, M195, A33, and MRK16 for application in the pharmacology and immunology projects. The pharmacology program studies tumor resistance to chemotherapy, particularly the phenomenon of multidrug resistance and the relationship between tumor uptake and retention and the tumor response for anti-metabolite drugs. The immunology program studies the physiology of antibody localization at the tissue level as the basis for novel approaches to improving tumor localization such as through the use of an artificial lymphatic system which mechanically reduces intratumoral pressures in tumors in vivo. Quantitative imaging approaches based on PET and SPECT in radioimmunotherapy are studied to give greater insight into the physiology of tumor localization and dosimetry.
- Research Organization:
- Sloan-Kettering Inst. for Cancer Research, New York, NY (United States)
- Sponsoring Organization:
- USDOE; USDOE, Washington, DC (United States)
- DOE Contract Number:
- FG02-86ER60407
- OSTI ID:
- 7262966
- Report Number(s):
- DOE/ER/60407-6; ON: DE92040305
- Country of Publication:
- United States
- Language:
- English
Similar Records
Improving cancer treatment with cyclotron produced radionuclides. [Multiple Drug Resistance (MDR)]
Quantitative imaging of I-124 using positron emission tomography with applications to radioimmunodiagnosis and radioimmunotherapy
Related Subjects
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
RADIOPHARMACEUTICALS
CHEMICAL PREPARATION
URIDINE
LABELLING
CYCLOTRONS
FLUORINE 18
GALLIUM 66
IMMUNOGLOBULINS
IODINE 124
NUCLEAR MEDICINE
PATIENTS
POSITRON COMPUTED TOMOGRAPHY
PROGRESS REPORT
RADIOCHEMISTRY
RADIOIMMUNOTHERAPY
ACCELERATORS
AZINES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
CHEMISTRY
COMPUTERIZED TOMOGRAPHY
CYCLIC ACCELERATORS
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DOCUMENT TYPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
FLUORINE ISOTOPES
GALLIUM ISOTOPES
GLOBULINS
HETEROCYCLIC COMPOUNDS
HOURS LIVING RADIOISOTOPES
HYDROXY COMPOUNDS
IMMUNOLOGY
IMMUNOTHERAPY
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MEDICINE
NANOSEC LIVING RADIOISOTOPES
NUCLEI
NUCLEOSIDES
NUCLEOTIDES
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PROTEINS
PYRIMIDINES
RADIOIMMUNOLOGY
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RIBOSIDES
SYNTHESIS
THERAPY
TOMOGRAPHY
URACILS
550603* - Medicine- External Radiation in Therapy- (1980-)
400703 - Radiochemistry & Nuclear Chemistry- Radioisotope Production