Improving cancer treatment with cyclotron produced radionuclides. Progress report

Technical Report · Tue Aug 04 04:00:00 EDT 1992

DOI:https://doi.org/10.2172/10177525· OSTI ID:10177525

Larson, S M; Finn, R D

Our goal is to improve the scientific basis for tumor diagnosis, treatment and treatment follow-up based on the use of cyclotron produced radiotracers in oncology. The grant includes 3 interactive components: Radiochemistry/Cyclotron; Pharmacology; and Immunology. The radiochemistry group seeks to develop innovative cyclotron targetry, radiopharmaceuticals, and radiolabeled antibodies, which are then used to assess important unanswered questions in tumor pharmacology and immunology. Examples include selected positron emitting radionuclides, such as Iodine-124, and Ga-66; I-124, I-123, I-131 labeled iododeoxyuridine, C-11 colchicine, and antimetabolites, like C-11 methotrexate; and radiolabeled antibodies, 3F8, M195, A33, and MRK16 for application in the pharmacology and immunology projects. The pharmacology program studies tumor resistance to chemotherapy, particularly the phenomenon of multidrug resistance and the relationship between tumor uptake and retention and the tumor response for anti-metabolite drugs. The immunology program studies the physiology of antibody localization at the tissue level as the basis for novel approaches to improving tumor localization such as through the use of an artificial lymphatic system which mechanically reduces intratumoral pressures in tumors in vivo. Quantitative imaging approaches based on PET and SPECT in radioimmunotherapy are studied to give greater insight into the physiology of tumor localization and dosimetry.

• Research Organization: Sloan-Kettering Inst. for Cancer Research, New York, NY (United States)
• Sponsoring Organization: USDOE, Washington, DC (United States)
• DOE Contract Number: FG02-86ER60407
• OSTI ID: 10177525
• Report Number(s): DOE/ER/60407--6; ON: DE92040305
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400703
550603
62 RADIOLOGY AND NUCLEAR MEDICINE
CHEMICAL PREPARATION
CYCLOTRONS
EXTERNAL RADIATION IN THERAPY
FLUORINE 18
GALLIUM 66
IMMUNOGLOBULINS
IODINE 124
LABELLING
NUCLEAR MEDICINE
PATIENTS
POSITRON COMPUTED TOMOGRAPHY
PROGRESS REPORT
RADIOCHEMISTRY
RADIOIMMUNOTHERAPY
RADIOISOTOPE PRODUCTION
RADIOPHARMACEUTICALS
URIDINE