How x rays inhibit amphibian limb regeneration
Journal Article
·
· J. Exp. Zool.; (United States)
The effects of an inhibiting dose of 2,000 rad of x-rays on the regenerating limbs of axolotl larvae have been examined in a histological and cytological study. Particular attention was paid to the mitotic indices of normal and irradiated epidermal and blastemal cells. Both the characteristic pattern of epidermal mitotic stimulation which normally follows amputation and the later increase in blastemal mitoses are suppressed by irradiation. In most cells the effects are permanent, but in a small proportion a mitotic delay is induced and upon subsequent division chromosome damage in the form of micronuclei is revealed. Thus irradiated cells which do divide almost certainly die. These results are discussed in relation to other theories of x-ray inhibition of regeneration with particular reference to the view that irradiated cells can be reactivated.
- Research Organization:
- Univ. of Birmingham, Eng.
- OSTI ID:
- 7259736
- Journal Information:
- J. Exp. Zool.; (United States), Journal Name: J. Exp. Zool.; (United States) Vol. 197:1; ISSN JEZOA
- Country of Publication:
- United States
- Language:
- English
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Journal Article
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Sun Feb 29 23:00:00 EST 1976
· J. Exp. Zool.; (United States)
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OSTI ID:7245523
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Journal Article
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Thu Jul 01 00:00:00 EDT 1982
· J. Exp. Zool.; (United States)
·
OSTI ID:6564315
VARIATION IN THE CONTENT OF NUCLEIC ACIDS IN THE EXTREMITIES OF AXOLOTLS AFTER IRRADIATION WITH X-RAYS AND AFTER RE-ESTABLISHMENT OF THE ABILITY TO REGENERATE THE EXTREMITIES
Journal Article
·
Wed Oct 31 23:00:00 EST 1962
· Doklady Akademii Nauk SSSR (U.S.S.R.) English translation currently published in a number of subject-oriented journals
·
OSTI ID:4743800
Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMPHIBIANS
ANIMALS
AQUATIC ORGANISMS
AXOLOTL
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REGENERATION
BODY
BODY AREAS
CELL DIVISION
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
IRRADIATION
LARVAE
LIMBS
MITOSIS
RADIATION EFFECTS
RADIATIONS
RECOVERY
SALAMANDERS
VERTEBRATES
X RADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMPHIBIANS
ANIMALS
AQUATIC ORGANISMS
AXOLOTL
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REGENERATION
BODY
BODY AREAS
CELL DIVISION
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
IRRADIATION
LARVAE
LIMBS
MITOSIS
RADIATION EFFECTS
RADIATIONS
RECOVERY
SALAMANDERS
VERTEBRATES
X RADIATION