Radiofrequency radiation-induced calcium-ion-efflux enhancement from human and other neuroblastoma cells in culture: (Final technical report)

Technical Report · Fri Jan 01 04:00:00 EST 1988

OSTI ID:7252686

Dutta, S K; Ghosh, B; Blackman, C F

In order to test the generality of radiofrequency-radiation-induced change in alternation of /sup 45/Ca/sup 2/plus// efflux from avian and feline brain tissues, human neuroblastoma cells were exposed to electromagnetic radiation at 147 MHz, amplitude modulated (AM) at 16 Hz, at specific absorption rates (SAR) of 0.1, 0.05, 0.01, 0.005, 0.001, and 0.0005 Wkg. Significant /sup 45/Ca/sup 2/plus// efflux was obtained at SAR values of 0.05 and 0.005 Wkg. Enchanced efflux at 0.05 Wkg peaked at the 13-to-16 Hz and at the 57.5-to-60 Hz modulation ranges. A Chinese hamster-mouse hybrid neuroblastoma was also shown to exhibit enchanced radiation-induced /sup 45/Ca/sup 2/plus// efflux at an SAR of 0.05 Wkg, using 147 MHz, AM at 16 hz. These results confirm that amplitude-modulated radiofrequency radiation can induce response in cells of nervous tissue origin from widely different animal species including humans. The results are also consistent with reports of similar findings in avian and feline brain tissue reported by others and indicate the general nature of the phenomenon. 9 refs., 3 tabs.

• Research Organization: Howard Univ., Washington, DC (USA); Environmental Protection Agency, Research Triangle Park, NC (USA). Health Effects Research Lab.
• DOE Contract Number: AI06-87RL11374
• OSTI ID: 7252686
• Report Number(s): DOE/RL/11374-T1; ON: DE88011609
• Country of Publication: United States
• Language: English

Related Subjects

550501 -- Metabolism-- Tracer Techniques
560120* -- Radiation Effects on Biochemicals
Cells
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59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH ISOTOPES
ANIMAL CELLS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CALCIUM 45
CALCIUM ISOTOPES
CELL CULTURES
DAYS LIVING RADIOISOTOPES
DOCUMENT TYPES
DOSE RATES
ELECTROMAGNETIC RADIATION
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
NERVE CELLS
NUCLEI
PROGRESS REPORT
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIOWAVE RADIATION
SOMATIC CELLS
TRACER TECHNIQUES