Dopamine D sub 2 receptors in the cerebral cortex: Distribution and pharmacological characterization with ( sup 3 H)raclopride

Journal Article · Tue Aug 01 04:00:00 EDT 1989 · Proceedings of the National Academy of Sciences of the United States of America; (USA)

DOI:https://doi.org/10.1073/pnas.86.16.6412· OSTI ID:7244609

Lidow, M S; Goldman-Rakic, P S; Rakic, P; Innis, R B ^[1]

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1. Yale Univ., New Haven, CT (USA)

An apparent involvement of dopamine in the regulation of cognitive functions and the recognition of a widespread dopaminergic innervation of the cortex have focused attention on the identity of cortical dopamine receptors. However, only the presence and distribution of dopamine D{sub 1} receptors in the cortex have been well documented. Comparable information on cortical D{sub 2} sites is lacking. The authors report here the results of binding studied in the cortex and neostriatum of rat and monkey using the D{sub 2} selective antagonist ({sup 3}H)raclopride. In both structures ({sup 3}H)raclopride bound in a sodium-dependent and saturable manner to a single population of sites with pharmacological profiles of dopamine D{sub 2} receptors. D{sub 2} sites were present in all regions of the cortex, although their density was much lower than in the neostriatum. The density of these sites in both monkey and, to a lesser extent, rat cortex displayed a rostral-caudal gradient with highest concentrations in the prefrontal and lowest concentrations in the occipital cortex, corresponding to dopamine levels in these areas. Thus, the present study established the presence and widespread distribution of dopamine D{sub 2} receptors in the cortex.

• OSTI ID: 7244609
• Journal Information: Proceedings of the National Academy of Sciences of the United States of America; (USA), Journal Name: Proceedings of the National Academy of Sciences of the United States of America; (USA) Vol. 86:16; ISSN PNASA; ISSN 0027-8424
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALKALI METAL COMPOUNDS
ALKALINE EARTH METAL COMPOUNDS
AMINES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BODY
BRAIN
CALCIUM COMPOUNDS
CARDIOTONICS
CARDIOVASCULAR AGENTS
CATIONS
CENTRAL NERVOUS SYSTEM
CEREBRUM
CHARGED PARTICLES
CHEMICAL REACTIONS
CROSS-LINKING
DISTRIBUTION
DOPAMINE
DOSE-RESPONSE RELATIONSHIPS
DRUGS
HYDROGEN COMPOUNDS
HYDROXY COMPOUNDS
IONS
MAGNESIUM COMPOUNDS
MAMMALS
MEMBRANE PROTEINS
MONKEYS
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANS
PHARMACOLOGY
PHENOLS
POLYMERIZATION
POLYPHENOLS
PRIMATES
PROTEINS
RATS
RECEPTORS
RODENTS
SODIUM COMPOUNDS
SYMPATHOMIMETICS
TEMPERATURE DEPENDENCE
TISSUE DISTRIBUTION
TRITIUM COMPOUNDS
VERTEBRATES