Widespread distribution of brain dopamine receptors evidenced with (/sup 125/I)iodosulpride, a highly selective ligand

Journal Article · Fri May 10 04:00:00 EDT 1985 · Science (Washington, D.C.); (United States)

DOI:https://doi.org/10.1126/science.3838821· OSTI ID:5219638

Martres, M P; Bouthenet, M L; Sales, N; Sokoloff, P; Schwartz, J C

The new benzamide derivative (/sup 125/I)iodosulpride is a highly sensitive and selective ligand for D-2 dopamine receptors and displays a very low nonspecific binding to membrane or autoradiographic sections. On autoradiographic images, D-2 receptors are present not only in well-established dopaminergic areas but also, in a discrete manner, in a number of catecholaminergic regions in which the dopaminergic innervation is still unknown, imprecise, or controversial, as in the sensorimotor cerebral cortex or cerebellum. This widespread distribution suggests larger physiological and pathophysiological roles for cerebral dopamine receptors than was previously thought.

• Research Organization: Centre Paul Broca de l'INSERM, Paris, France
• OSTI ID: 5219638
• Journal Information: Science (Washington, D.C.); (United States), Journal Name: Science (Washington, D.C.); (United States) Vol. 4700; ISSN SCIEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMIDES
AMINES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
AUTORADIOGRAPHY
BETA DECAY RADIOISOTOPES
BODY
BRAIN
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM
CEREBELLUM
CEREBRAL CORTEX
CEREBRUM
DAYS LIVING RADIOISOTOPES
DISTRIBUTION
DOPAMINE
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HIPPOCAMPUS
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPES
LIGANDS
MAMMALS
NERVOUS SYSTEM
NEUROREGULATORS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PHENOLS
POLYPHENOLS
RADIOISOTOPES
RATS
RECEPTORS
RODENTS
SYMPATHOMIMETICS
TISSUE DISTRIBUTION
VERTEBRATES