Effect of captopril on renal blood flow in renal artery stenosis assessed by positron tomography with rubidium-82

Journal Article · Tue Mar 01 00:00:00 EST 1988 · Hypertension (Dallas); (United States)

DOI:https://doi.org/10.1161/01.HYP.11.3.217· OSTI ID:7241863

Tamaki, N; Alpert, N M; Rabito, C A; Barlai-Kovach, M; Correia, J A; Strauss, H W

The sequence and magnitude of acute changes in renal blood flow following administration of captopril were determined in a canine model of acute unilateral renal artery stenosis using rubidium-82 and positron emission tomography. Data were recorded in each of nine dogs under three conditions: 1) during a baseline control interval, 2) during renal artery stenosis, and 3) during stenosis with intravenous injection of captopril (1.2 mg/kg). Mean arterial blood pressure was 108 +/- 12 mm Hg at control, increased significantly to 125 +/- 13 mm Hg (p less than 0.01) during stenosis, and decreased to 98 +/- 13 mm/Hg (p less than 0.01) after captopril infusion. Mean renal blood flow was calculated using a steady state single compartment model from the images produced by positron emission tomography. The estimated flow to the affected kidney was 3.37 +/- 1.48 ml/min/g at control, 0.86 +/- 0.62 ml/min/g during stenosis (p less than 0.01), and 0.64 +/- 0.57 ml/min/g after captopril administration (p = NS compared with precaptopril value). The estimated flow to the contralateral kidney was minimally reduced from a baseline of 3.84 +/- 0.95 to 3.24 +/- 1.13 ml/min/g (p = NS) during stenosis and increased after captopril infusion (4.08 +/- 0.94 ml/min/g; p = 0.01). These data suggest that repetitive imaging with positron emission tomography can be used to delineate acute changes in renal perfusion following captopril administration.

• Research Organization: Massachusetts General Hospital, Boston (USA)
• OSTI ID: 7241863
• Journal Information: Hypertension (Dallas); (United States), Vol. 11:3
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ANTIHYPERTENSIVE AGENTS
BIOLOGICAL FUNCTIONS
KIDNEYS
BLOOD FLOW
POSITRON COMPUTED TOMOGRAPHY
UROGENITAL SYSTEM DISEASES
DIAGNOSIS
BIOLOGICAL MODELS
BLOOD PRESSURE
DOGS
DYNAMIC FUNCTION STUDIES
RUBIDIUM 82
ALKALI METAL ISOTOPES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR AGENTS
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
FUNCTIONS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOTOPES
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
ORGANS
RADIOISOTOPES
RUBIDIUM ISOTOPES
TOMOGRAPHY
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics