Renal artery stenosis detection by combined Gates' technique and captopril test in hypertensive patients

Journal Article · Sun Jan 01 00:00:00 EST 1989 · J. Nucl. Med.; (United States)

OSTI ID:6406722

Cuocolo, A; Esposito, S; Volpe, M; Celentano, L; Brunetti, A; Salvatore, M

We studied 11 hypertensive patients by a radionuclide technique using Gates' method with (/sup 99m/Tc)DTPA to investigate the acute effects of captopril on glomerular filtration rate (GFR). Five patients had hypertension with unilateral renal artery stenosis (RAS) angiographically documented and six patients had essential hypertension (EH). Total and split GFR were determined under control conditions and after oral administration of captopril (50 mg). In the patients with RAS, captopril induced a significant decrease of GFR in the stenotic kidneys (from 42.4 +/- 4 to 29.6 +/- 3 ml/min, p less than 0.01), while no changes were observed in the nonstenotic kidneys (from 61.2 +/- 3 to 61.6 +/- 5 ml/min, NS). Total GFR was 103.6 +/- 5 ml/min under control conditions and decreased to 91.8 +/- 6 ml/min after captopril (p less than 0.05). No significant changes of GFR were detected after captopril administration in patients with EH. In a separate group of ten patients with EH, good correlation between 24-hr creatinine clearance and fractional uptake of (/sup 99m/Tc)DTPA was obtained. Good reproducibility of this radionuclide technique was also shown. This study demonstrates that the computed radionuclide GFR determination coupled with the captopril test allows one to unmask angiotensin II-dependent renal function and hemodynamic changes. This technique can be useful in clinical practice for identifying patients with renovascular hypertension.

• Research Organization: Universita di Napoli (Italy)
• OSTI ID: 6406722
• Journal Information: J. Nucl. Med.; (United States), Vol. 30:1
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
UROGENITAL SYSTEM DISEASES
DIAGNOSIS
VASODILATORS
BIOLOGICAL EFFECTS
ARTERIES
BLOOD PRESSURE
DTPA
HYPERTENSION
ISOMERIC NUCLEI
KIDNEYS
ORGANOMETALLIC COMPOUNDS
TECHNETIUM 99
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD VESSELS
BODY
CARBOXYLIC ACIDS
CARDIOVASCULAR AGENTS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CHELATING AGENTS
DISEASES
DRUGS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
SYMPTOMS
TECHNETIUM ISOTOPES
VASCULAR DISEASES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics