2[prime] and 3[prime] Carboranyl uridines and their diethyl ether adducts

Patent · Mon Dec 14 23:00:00 EST 1992

OSTI ID:7239400

Soloway, A H; Barth, R F; Anisuzzaman, A K; Alam, F; Tjarks, W

A process is described for preparing carboranyl uridine nucleoside compounds and their diethyl ether adducts, which exhibit a tenfold increase in boron content over prior art boron containing nucleoside compounds. The carboranyl uridine nucleoside compounds exhibit enhanced lipophilicity and hydrophilic properties adequate to enable solvation in aqueous media for subsequent incorporation of the compounds in methods for boron neutron capture therapy in mammalian tumor cells. No Drawings

• DOE Contract Number: FG02-90ER60972
• Assignee: Ohio State Univ. Research Foundation, Columbus, OH (United States)
• Patent Number(s): US 5171849; A
• Application Number: CNN: RO1 CA 41288; BNL 464374; PPN: US 7-688121
• OSTI ID: 7239400
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
AZINES
BORON COMPOUNDS
CHEMICAL PREPARATION
DISEASES
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
MEDICINE
NEOPLASMS
NEUTRON CAPTURE THERAPY
NEUTRON THERAPY
NUCLEAR MEDICINE
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRIMIDINES
RADIOLOGY
RADIOTHERAPY
RIBOSIDES
SYNTHESIS
THERAPEUTIC USES
THERAPY
URACILS
URIDINE
USES