Synthesis and evaluation of boron compounds for neutron capture therapy of malignant brain tumors

Technical Report · Tue Jan 01 04:00:00 EST 1991

OSTI ID:6146334

Soloway, A H

Current progress on this research includes the synthesis of chemical structures for malignant brain tumors. These structures include boron-containing derivatives of lipophilic anticonvulsants and CNS depressants; carboranyl precursors of nucleic acids and related structures; and carboranyl amino acids. Cellular uptake and persistence studies have also been carried out with F98 rat glioma cells. 1 fig., 1 tab.

• Research Organization: Ohio State Univ., Columbus, OH (USA)
• Sponsoring Organization: DOE/ER
• DOE Contract Number: FG02-90ER60972
• OSTI ID: 6146334
• Report Number(s): DOE/ER/60972-1; ON: DE91008452
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ANESTHETICS
ANIMAL CELLS
AZINES
BARBITURATES
BODY
BORON
BORON COMPOUNDS
BRAIN
CARBON COMPOUNDS
CARBORANES
CELL CONSTITUENTS
CELL NUCLEI
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DISEASES
DOCUMENT TYPES
DRUGS
ELEMENTS
EMISSION SPECTROSCOPY
GLIOMAS
HETEROCYCLIC COMPOUNDS
HYPNOTICS AND SEDATIVES
MEDICINE
NEOPLASMS
NERVOUS SYSTEM
NEUTRON CAPTURE THERAPY
NEUTRON THERAPY
NUCLEAR MEDICINE
ORGANIC BORON COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PROGRESS REPORT
PYRIMIDINES
RADIOLOGY
RADIOTHERAPY
RETENTION
SEMIMETALS
SPECTROSCOPY
SYNTHESIS
THERAPY
TUMOR CELLS
UPTAKE