Synthesis and evaluation of boron compounds for neutron capture therapy of malignant brain tumors
Boron neutron capture therapy offers the potentiality for treating brain tumors currently resistant to treatment. The success of this form of therapy is directly dependent upon the delivery of sufficient numbers of thermal-neutrons to tumor cells which possess high concentrations of B-10. The objective of this project is to develop chemical methodology to synthesize boron-containing compounds with the potential for becoming incorporated into rapidly-dividing malignant brain tumor cells and excluded from normal components of the brain and surrounding tissues, to develope biological methods for assessing the potential of the compound by use of cell culture or intratumoral injection, to develop analytical methodology for measuring boron in cells and tissue using direct current plasma atomic emission spectroscopy (DCP-AES) and alpha track autoradiography, to develop biochemical and HPLC procedures for evaluating compound uptake and tissue half-life, and to develop procedures required to assess both in vitro and vivo efficacy of BNCT with selected compounds.
- Research Organization:
- Ohio State Univ. Research Foundation, Columbus, OH (United States)
- Sponsoring Organization:
- DOE; USDOE, Washington, DC (United States)
- DOE Contract Number:
- FG02-90ER60972
- OSTI ID:
- 6375527
- Report Number(s):
- DOE/ER/60972-3; ON: DE93015880
- Country of Publication:
- United States
- Language:
- English
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37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400202 -- Isotope Effects
Isotope Exchange
& Isotope Separation
550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
AZINES
BORON COMPOUNDS
CELL CULTURES
CHEMICAL PREPARATION
DISEASES
DOCUMENT TYPES
DRUGS
EXPERIMENTAL NEOPLASMS
GLIOMAS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
LABELLED COMPOUNDS
LABELLING
MAMMALS
MEDICINE
NEOPLASMS
NEUTRON THERAPY
NUCLEAR MEDICINE
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PROGRESS REPORT
PYRIMIDINES
RADIOLOGY
RADIOPHARMACEUTICALS
RADIOTHERAPY
RATS
RIBOSIDES
RODENTS
SYNTHESIS
THERAPY
URACILS
URIDINE
VERTEBRATES
400202 -- Isotope Effects
Isotope Exchange
& Isotope Separation
550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
AZINES
BORON COMPOUNDS
CELL CULTURES
CHEMICAL PREPARATION
DISEASES
DOCUMENT TYPES
DRUGS
EXPERIMENTAL NEOPLASMS
GLIOMAS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
LABELLED COMPOUNDS
LABELLING
MAMMALS
MEDICINE
NEOPLASMS
NEUTRON THERAPY
NUCLEAR MEDICINE
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PROGRESS REPORT
PYRIMIDINES
RADIOLOGY
RADIOPHARMACEUTICALS
RADIOTHERAPY
RATS
RIBOSIDES
RODENTS
SYNTHESIS
THERAPY
URACILS
URIDINE
VERTEBRATES