Antibiotic radioprotection of mice exposed to supralethal whole-body irradiation independent of antibacterial activity. [Gamma radiation, streptomycin, kanamycin, neomycin, gentamycin]
Journal Article
·
· Radiat. Res.; (United States)
Oral administration of streptomycin, kanamycin, neomycin, or gentamicin to specific pathogen-free C57 x Af mice in their drinking water (4 mg/ml) for 2 weeks before supralethal whole-body irradiation very significantly prolonged their mean survival times (8.2 to 8.9 days vs 6.9 for controls) to values which exceed those reported for germ-free mice (7.3 days). The total fecal concentrations of aerobes and anaerobes were reduced by kanamycin, neomycin, and gentamicin. Streptomycin reduced the anaerobes significantly, but not the aerobes. Unlike germ-free mice, these antibiotic-treated mice did excrete free bile acids, products of bacterial action. Oral antibiotic treatment was ineffective in altering the transit time of the intestinal mucosal cells. Previously reported studies had indicated a correlation between decreased transit time and increased survival after irradiation. No significant correlation between mean survival time after irradiation and mucosal transit time was observed. The data demonstrate that certain antibiotics alter the character of the intestinal bacterial flora and increase protection against supralethal doses of whole-body irradiation. It is concluded that the mechanisms of radioresistance in antibiotic-treated mice and germ-free mice are different and that in both groups radioresistance is the result of more than elimination of postirradiation infection.
- Research Organization:
- Baylor Coll., Houston, TX
- OSTI ID:
- 7238548
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 68:2; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Increased intestinal mucosal turnover and radiosensitivity to supralethal whole-body irradiation resulting from cholic acid-induced alterations of the intestinal microecology of germfree CFW mice. [X radiation]
THE TREATMENT OF ACUTELY X-IRRADIATED MICE WITH STREPTOMYCIN AND DERIVATIVES OF 6-AMINOPENICILLANIC ACID
THE CAUSES OF UNSUCCESSFUL ANTIBIOTIC THERAPY OF AUTOINFECTION IN RADIATION SICKNESS
Journal Article
·
Sat May 01 00:00:00 EDT 1976
· Radiat. Res.; (United States)
·
OSTI ID:7275963
THE TREATMENT OF ACUTELY X-IRRADIATED MICE WITH STREPTOMYCIN AND DERIVATIVES OF 6-AMINOPENICILLANIC ACID
Journal Article
·
Wed Jan 31 23:00:00 EST 1962
· Brit. J. Exptl. Pathol.
·
OSTI ID:4750211
THE CAUSES OF UNSUCCESSFUL ANTIBIOTIC THERAPY OF AUTOINFECTION IN RADIATION SICKNESS
Journal Article
·
Thu Aug 01 00:00:00 EDT 1963
· Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR
·
OSTI ID:4164830
Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTIBIOTICS
BACTERIA
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DIGESTIVE SYSTEM
DRUGS
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
GAMMA RADIATION
GASTROINTESTINAL TRACT
INTESTINES
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MICE
MICROORGANISMS
ORGANS
RADIATION EFFECTS
RADIATION PROTECTION
RADIATIONS
RADIOSENSITIVITY EFFECTS
RODENTS
STREPTOMYCIN
SURVIVAL TIME
VERTEBRATES
WHOLE-BODY IRRADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTIBIOTICS
BACTERIA
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DIGESTIVE SYSTEM
DRUGS
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
GAMMA RADIATION
GASTROINTESTINAL TRACT
INTESTINES
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MICE
MICROORGANISMS
ORGANS
RADIATION EFFECTS
RADIATION PROTECTION
RADIATIONS
RADIOSENSITIVITY EFFECTS
RODENTS
STREPTOMYCIN
SURVIVAL TIME
VERTEBRATES
WHOLE-BODY IRRADIATION