Synthesis and testing of tetrodotoxin and batrachotoxin antagonists. Annual report, 1 February 1987-31 January 1988
Technical Report
·
OSTI ID:7226927
Compounds have been designed and synthesized as potential antagonists to the neurotoxin batrachotoxin. The compounds synthesized to date have moderate to low affinity for the batrachotoxin binding site. Their potential as antagonists of batrachotoxin or veratridine-induced Na-flux in neuroblastoma cells is currently under investigation. The synthesis of analogs which should have increased affinity for the batrachotoxin binding site is continuing. We have also begun the synthesis of potential antagonists to the neurotoxin tetrodotoxin.
- Research Organization:
- SRI International, Menlo Park, CA (United States)
- OSTI ID:
- 7226927
- Report Number(s):
- AD-B-123431/9/XAB; CNN: DAMD17-86-C-6060
- Country of Publication:
- United States
- Language:
- English
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