Synthesis and testing of tetrodotoxin and batrachotoxin antagonists. Annual report, 1 February 1986-31 January 1987
Technical Report
·
OSTI ID:6957180
There are numerous neurotoxins in the environment that could potentially be used as chemical warfare agents. Some of the most potent agents are compounds that affect the voltage-dependent sodium channel. Tetrodotoxin (TTX) and its analog saxitoxin (STX) are heterocyclic guanidines that bind to a high-affinity site on the channel protein and block sodium flux. Batrachotodin (BTX) and veratridine are lipophilic compounds that bind to a different site on the channel, and persistently activate it. Ultimately, both types of compounds block impulse conduction and can produce various central nervous system-related and peripheral consequences. Our objective is to synthesize and evaluate potential antagonists to the neurotoxins TTX and BTX.
- Research Organization:
- SRI International, Menlo Park, CA (United States)
- OSTI ID:
- 6957180
- Report Number(s):
- AD-B-111835/5/XAB; CNN: DAMD17-86-C-6060
- Country of Publication:
- United States
- Language:
- English
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