Comparison of total body and local spinal cord irradiation in experimental allergic encephalomyelitis. [X and gamma radiation, tritium]

Journal Article · Sat Jan 01 04:00:00 EST 1977 · J. Neuropathol. Exp. Neurol.; (United States)

DOI:https://doi.org/10.1097/00005072-197701000-00006· OSTI ID:7226180

Oldendorf, W H ^[1]; Cornford, E M

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1. Veterans Administration Center, Los Angeles

Spinal cord distribution spaces of /sup 3/H-mannitol (M.W. 182) were measured to compare the effects of both total-body gamma irradiation and local (spinal cord) x-irradiation on the development of experimental allergic encephalomyelitis (EAE). Single doses of 700 R, 500 R, 300 R, 200 R and 100 R total body gamma irradiation, administered 6 to 8 days after EAE induction, appeared to delay the onset, reduce the severity, and hasten recovery of the disease. The magnitude of this effect was approximately proportional to the administered radiation dose. A single 1000 R x-irradiation dose, delivered to a 1 x 2 cm area in the thoracolumbar region of the spinal cord 7 or 10 days after induction appeared to increase the severity of EAE. Mannitol distribution spaces were mildly elevated in the thoracic regions and significantly elevated in the lumbar spinal cords of cord-irradiated animals. A marked exacerbation of the disease was observed in cord-irradiated rats treated with 5000 R, administered over a period of 5 days. Rats progressively lost weight during the normal course of EAE, and a simultaneous increase in wet weights of the spinal cords was seen. Slight changes in these two parameters were observed in cord-irradiated, but not in total-body irradiated, animals.

• OSTI ID: 7226180
• Journal Information: J. Neuropathol. Exp. Neurol.; (United States), Journal Name: J. Neuropathol. Exp. Neurol.; (United States) Vol. 36:1; ISSN JNENA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CENTRAL NERVOUS SYSTEM
COMPARATIVE EVALUATIONS
DISEASES
DISTRIBUTION
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
ENCEPHALITIS
EXTERNAL IRRADIATION
GAMMA RADIATION
HYDROGEN ISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOTOPES
LIGHT NUCLEI
LOCAL IRRADIATION
MAMMALS
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
NUCLEI
ODD-EVEN NUCLEI
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RATS
RODENTS
SPINAL CORD
TRITIUM
VERTEBRATES
WHOLE-BODY IRRADIATION
X RADIATION
YEARS LIVING RADIOISOTOPES