Cellular interactions controlling the immune reactivity of T-lymphocytes

Journal Article · Fri Feb 28 00:00:00 EDT 1975 · Ann. N.Y. Acad. Sci.; (United States)

DOI:https://doi.org/10.1111/j.1749-6632.1975.tb29061.x· OSTI ID:7220770

Cohen, I R; Feldman, M

The sequence of developmental processes of thymus-derived lymphocytes can be classified into two distinct stages. The first stage constitutes the appearance of lymphocytes in the thymus capable of recognizing antigenic signals. Such lymphocytes leave the thymus and colonize the spleen and lymph nodes. The second stage involves the response of thymocytes to antigenic signals. When a given cell-bound antigen triggers thymocytes capable of recognizing the antigen killer cells develop capable of lysing target cells possessing the same surface antigens that triggered their development. Studies indicated that both these stages are regulated by cell interactions. Results of the following studies are reported: in vitro induction of T-cell properties by thymus reticulum cells; interactions between thymocytes and the differentiation of effector cells; and control of the differentiation of effector lymphocytes by suppressor T-cells. (HLW)

• Research Organization: Weizmann Inst. of Science, Rehovot, Israel
• OSTI ID: 7220770
• Journal Information: Ann. N.Y. Acad. Sci.; (United States), Journal Name: Ann. N.Y. Acad. Sci.; (United States) Vol. 249; ISSN ANYAA
• Country of Publication: United States
• Language: English

Related Subjects

550300* -- Cytology
550500 -- Metabolism
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANTIGENS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CELL DIFFERENTIATION
CONNECTIVE TISSUE CELLS
IMMUNE REACTIONS
LEUKOCYTES
LYMPH NODES
LYMPHATIC SYSTEM
LYMPHOCYTES
ORGANS
SOMATIC CELLS
SPLEEN
THYMOCYTES
THYMUS