Clinical comparison of /sup 127/Xe and /sup 133/Xe for ventilation studies. [/sup 99m/Tc]

Journal Article · Fri Jul 01 04:00:00 EDT 1977 · J. Nucl. Med.; (United States)

OSTI ID:7220768

Atkins, H L; Susskind, H; Klopper, J F; Ansari, A N; Richards, P; Fairchild, R G

Xenon-133 and xenon-127 were compared by performing ventilation studies with both radionuclides in 19 patients with a variety of lung diseases. Assessment of the counting rate over the chest, relative to the radioactivity in the lungs, permitted the evaluation of each isotope in terms of usable photons detected by a scintillation camera with a large field of view and appropriate collimation. A greater photon yield was obtained with Xe-127. Markedly improved resolution was shown by measurement of a line phantom, but was not apparent on subjective appraisal of scintiphotos except in the washout phase. Xenon-127 appears to be preferable to Xe-133 because of the higher counting rates, lower patient radiation dose, and longer shelf life. In addition, a prior perfusion study using a Tc-99m radiopharmaceutical does not affect the quality of a Xe-127 ventilation study. The use of Xe-127 therefore permits the selection for ventilation studies of only those patients with suspected pulmonary embolism, and eliminates unnecessary radiation exposure. A further improvement in image quality obtained with Xe-127 should be possible with certain modifications of the scintillation camera that would permit use of the 375-keV photopeak along with the 172- and 203-keV gamma energies. Charcoal traps designed for Xe-133 will require additional shielding and longer storage time when used for Xe-127. Xenon-127, however, might be used again after appropriate processing.

• Research Organization: Brookhaven National Lab., Upton, NY
• OSTI ID: 7220768
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 18:7; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CAMERAS
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DOSES
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTARY PARTICLES
EVEN-ODD NUCLEI
HOURS LIVING RADIOISOTOPES
IMAGES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LUNGS
MASSLESS PARTICLES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATIENTS
PHOTONS
PHYSIOLOGY
RADIATION DOSES
RADIOACTIVITY
RADIOISOTOPE SCANNING
RADIOISOTOPES
RESPIRATORY SYSTEM
SCINTISCANNING
SECONDS LIVING RADIOISOTOPES
TECHNETIUM 99
TECHNETIUM ISOTOPES
XENON 127
XENON 133
XENON ISOTOPES
YEARS LIVING RADIOISOTOPES