Efficacy of prophylactic irradiation in altering renal allograft survival

Journal Article · Tue Jan 01 04:00:00 EST 1974 · Proc. Clin. Dial. Transplant Forum; (United States)

OSTI ID:7220751

Faber, R; Johnson, H K; Braren, H V; Richie, R E

Renal allograft rejection is a complex phenomenon involving both cell-mediated and humoral antibody responses. Most transplant programs have used a combination of therapeutic modalites to combat the immune system in an attempt to prolong both allograft and patient survival. Corticosteroids (methylprednisolone (Solu-Medrol) and prednisone and azathioprine (Imuran) are widely accepted as immunosuppressive drugs; however, both are non-specific and have the disadvantage of compromising the recipients' defense mechanisms. Nevertheless, these drugs have proved to be essential to the success of renal transplantation and they are routinely used while the efficacy of other modalities continues to be evaluated. We could find no reports of a prospective study to evaluate the efficacy of prophylactic irradiation in the complex therapeutic situation of renal transplantation with the only variable being the administration of local graft irradiation. The purpose of this study was to evaluate prophylactic graft irradiation for its effectiveness in preventing graft rejection in conjunction with Imuran and corticosteroids.

• Research Organization: Vanderbilt Univ., Nashville
• OSTI ID: 7220751
• Journal Information: Proc. Clin. Dial. Transplant Forum; (United States), Journal Name: Proc. Clin. Dial. Transplant Forum; (United States) Vol. 4; ISSN PCDFD
• Country of Publication: United States
• Language: English

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