Effect of blood transfusions on canine renal allograft survival

Journal Article · Thu Apr 01 04:00:00 EST 1982 · Transplantation; (United States)

DOI:https://doi.org/10.1097/00007890-198204000-00011· OSTI ID:7085289

van der Linden, C J; Buurman, W A; Vegt, P A; Greep, J M; Jeekel, J

In this study significantly prolonged canine renal allograft survival has been demonstrated after transfusion of 100 ml of third-party whole blood given peroperatively. Peroperative transfusions of third-party leukocyte-free blood or pure lymphocyte cell suspensions did not influence graft survival. Furthermore, no improvement in graft survival has been found after a peroperative transfusion of irradiated whole blood (2500 rad). These data suggest that delayed graft rejection after blood transfusions can only be expected after the administration of whole blood. The role of competent lymphocytes in whole blood is questionable, since a transfusion or irradiated whole blood in combination with nonirradiated lymphocytes did not lead to prolonged graft survival. Immunosuppression of the recipient directly after transfusion seems to be essential to induce the beneficial effect of blood transfusions. This has been demonstrated for a transfusion of whole blood 14 days before transplantation. A single transfusion of 100 ml of whole blood 14 days before transplantation could effectively prolong graft survival if immunosuppression with azathioprine and prednisone was started on the day of transfusion. No improvement in graft survival has been found with such a transfusion if preoperative immunosuppression has been omitted.

• Research Organization: Department of Surgery, Hospital St. Annadal, Maastricht, The Netherlands
• OSTI ID: 7085289
• Journal Information: Transplantation; (United States), Journal Name: Transplantation; (United States) Vol. 33:4; ISSN TRPLA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DOGS
DOSES
EXTERNAL IRRADIATION
EXTRACORPOREAL IRRADIATION
GRAFT-HOST REACTION
GRAFTS
IMMUNOSUPPRESSION
IRRADIATION
KIDNEYS
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
ORGANS
RADIATION DOSES
RADIATION EFFECTS
SOMATIC CELLS
THERAPY
TRANSFUSIONS
TRANSPLANTS
VERTEBRATES