Studies on /sup 133/Xe wash-out from human skin: quantitative measurements of blood flow in normal and corticosteroid-treated skin

Journal Article · Fri Apr 01 00:00:00 EST 1977 · J. Invest. Dermatol.; (United States)

DOI:https://doi.org/10.1111/1523-1747.ep12492755· OSTI ID:7219804

Kristensen, J K; Wadskov, S

Blood flow was measured by the /sup 133/Xe technique in normal and corticosteroid-treated skin. Epicutaneous and intracutaneous methods of tracer application were compared in normal skin. The two labeling methods were equally suitable for measuring cutaneous blood flow provided calculations in both cases were based on a biexponential resolution of the wash-out curve in its cutaneous and subcutaneous components and provided the traumatic hyperemia phase was considered, when intracutaneous application of the tracer was used. Results were invalidated if calculations were based on initial slope of the washout curves. Topical application of beta-methasone valerate resulted in a reduction in cutaneous blood flow as measured by the intracutaneous technique with curve resolution, whereas no effect could be demonstrated when calculations were based on the initial slopes of the curves. The /sup 133/Xe technique is a simple and reliable method for measuring cutaneous blood flow, which might prove useful in estimations of penetration ability and potency of topical corticosteroids.

• Research Organization: Univ. of Copenhagen (Denmark)
• OSTI ID: 7219804
• Journal Information: J. Invest. Dermatol.; (United States), Vol. 68:4
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BLOOD FLOW
MEASURING METHODS
SKIN
CORTICOSTEROIDS
MAN
XENON 133
ADRENAL HORMONES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
DAYS LIVING RADIOISOTOPES
EVEN-ODD NUCLEI
HORMONES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KETONES
MAMMALS
NUCLEI
ORGANIC COMPOUNDS
ORGANS
PREGNANES
PRIMATES
RADIOISOTOPES
STEROID HORMONES
STEROIDS
VERTEBRATES
XENON ISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics