Skin blood flow in sheep: comparison of xenon-133 washout and radioactive microsphere techniques

Journal Article · Tue Sep 01 00:00:00 EDT 1987 · J. Appl. Physiol.; (United States)

OSTI ID:5840486

Midtgard, U H; Hales, J R; Fawcett, A A; Sejrsen, P

Blood flow was measured in leg and torso skin of conscious or anesthetized sheep by using 15-micron radioactive microspheres (Qm) and the /sup 133/Xe washout method (QXe). There was a good relationship between Qm in the cutaneous compartment and QXe calculated from the fast component of the biexponential washout curves (QXe = 0.40.Qm + 6.2, r = 0.90, P less than 0.001) with QXe values substantially below those determined with microspheres. Only at low blood flow levels was there a tendency for QXe to overestimate capillary blood flow as assessed with microspheres, but at higher blood flow levels the /sup 133/Xe washout method resulted in values substantially below those determined with microspheres. The slope of the slow component of the washout curves was inversely related to the tissue-blood partition coefficient in the subcutaneous tissue (r = 0.52, P less than 0.001), indicating an influence of the amount of subcutaneous fat on the washout rate. QXe calculated from the slow component of the washout curves was not significantly correlated with Qm in the subcutaneous compartment (r = 0.19, P greater than 0.10). In leg skin with dilated arteriovenous anastomoses, QXe was generally higher than in torso skin and leg skin with constricted arteriovenous anastomoses, indicating that shunt blood flow increases the washout of /sup 133/Xe.

• Research Organization: Univ. of Copenhagen, Denmark
• OSTI ID: 5840486
• Journal Information: J. Appl. Physiol.; (United States), Vol. 63:3
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
SKIN
BLOOD FLOW
CAPILLARIES
MICROSPHERES
SHEEP
TRACER TECHNIQUES
XENON 133
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD VESSELS
BODY
CARDIOVASCULAR SYSTEM
DAYS LIVING RADIOISOTOPES
DOMESTIC ANIMALS
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
NUCLEI
ORGANS
RADIOISOTOPES
RUMINANTS
VERTEBRATES
XENON ISOTOPES
551001* - Physiological Systems- Tracer Techniques