Review of the carcinogenicities of nickel, chromium, and arsenic compounds in man and animals

Journal Article · Thu Jan 01 04:00:00 EST 1976 · Prev. Med.; (United States)

DOI:https://doi.org/10.1016/0091-7435(76)90045-1· OSTI ID:7216519

Sunderman, Jr, F W

Increased incidences of cancer of the respiratory tract have been reported among workers in nickel refineries; industrial workers who have been engaged in production of chromates or in processing of chrome pigments; and workers who have had diverse occupational exposures to arsenic compounds (metallurgical, chemical and agricultural workers). Human subjects who have developed clinical manifestations of arsenicalism as a result of environmental, occupational or iatrogenic exposures have been reported to have increased incidences of cancers of the skin and possibly of internal organs. Certain nickel and chromium compounds (e.g., nickel subsulfide and calcium chromate) that have been administered to rodents by parenteral or respiratory routes have induced cancers at the sites of deposition. Experimental induction of cancers in animals has not been reported as a consequence of administration of arsenic compounds.

• Research Organization: Univ. of Connecticut, Farmington
• OSTI ID: 7216519
• Journal Information: Prev. Med.; (United States), Journal Name: Prev. Med.; (United States) Vol. 5; ISSN PVTMA
• Country of Publication: United States
• Language: English

Related Subjects

560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ARSENIC COMPOUNDS
BIOLOGICAL EFFECTS
BODY
CARCINOGENESIS
CHROMIUM COMPOUNDS
DISEASES
INDUSTRY
MAMMALS
NEOPLASMS
NICKEL COMPOUNDS
OCCUPATIONAL DISEASES
ORGANS
PATHOGENESIS
PERSONNEL
RESPIRATORY SYSTEM
RODENTS
SKIN
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES