New method of determining the fraction of hypoxic cells in a transplantable murine sarcoma. [Nitrogen mustard, gamma radiation]
Journal Article
·
· Radiat. Res.; (United States)
Combined nitrogen mustard and radiation treatments of KHT sarcoma in vivo have indicated that a certain dose of nitrogen mustard can kill all the oxygenated cells in the tumor while killing few, if any, of the hypoxic cells. This finding has allowed nitrogen mustard treatment to be used as a way of selectively removing the oxygenated cells in the tumor so that the radiation response of the hypoxic cells can be studied directly. Using this nitrogen mustard technique the hypoxic fraction is found to be 0.30 as compared to a value of 0.13 obtained using the more conventional technique of comparing anoxic and air-breathing survival data following the same dose of radiation. Also, chronically hypoxic cells have been found to have a smaller shoulder on their radiation survival curve than acutely hypoxic cells.
- Research Organization:
- Ontario Cancer Inst., Toronto
- OSTI ID:
- 7215292
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 70:1; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Combined nitrogen mustard: radiation studies with a mouse tumor
Smoking: the influence of carboxyhemoglobin (HbCO) on tumor oxygenation and response to radiation. [X rays; mice; transplantable KHT sarcomas]
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Conference
·
Sat Sep 01 00:00:00 EDT 1979
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
·
OSTI ID:5333911
Smoking: the influence of carboxyhemoglobin (HbCO) on tumor oxygenation and response to radiation. [X rays; mice; transplantable KHT sarcomas]
Journal Article
·
Sat Dec 31 23:00:00 EST 1977
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
·
OSTI ID:6540423
Combinations of radiation and misonidazole in a murine lung tumor model. [/sup 137/Cs]
Journal Article
·
Fri May 01 00:00:00 EDT 1981
· Radiat. Res.; (United States)
·
OSTI ID:6460284
Related Subjects
560152* -- Radiation Effects on Animals-- Animals
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYLATING AGENTS
AMINES
ANIMAL CELLS
ANIMALS
ANOXIA
ANTIMITOTIC DRUGS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
IONIZING RADIATIONS
MAMMALS
MICE
NEOPLASMS
NITROGEN MUSTARD
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RODENTS
SARCOMAS
SURVIVAL TIME
TRANSPLANTS
TUMOR CELLS
VERTEBRATES
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYLATING AGENTS
AMINES
ANIMAL CELLS
ANIMALS
ANOXIA
ANTIMITOTIC DRUGS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
IONIZING RADIATIONS
MAMMALS
MICE
NEOPLASMS
NITROGEN MUSTARD
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RODENTS
SARCOMAS
SURVIVAL TIME
TRANSPLANTS
TUMOR CELLS
VERTEBRATES