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Combined nitrogen mustard: radiation studies with a mouse tumor

Conference · · Int. J. Radiat. Oncol., Biol. Phys.; (United States)
OSTI ID:5333911
The KHT sarcoma, growing in C3H mice, has been treated with nitrogen mustard and irradiation and the response studied as a function of time between the treatments. Two series of experiments have been done and they indicate that a greater response is observed if nitrogen mustard is given before irradiation than if it is given a few hours afterwards. A detailed analysis of the first series of experiments indicated that reoxygenation could occur after drug treatment (within 1 hour) and that at the dose level used (0.2 mg/mouse) nitrogen mustard treatment preferentially spared the hypoxic cells. Such an analysis has not been completed for the second series of experiments but there are some definite differences between the two groups of experiments, which seem to be due to a change in the response of the tumor to treatment with nitrogen mustard.
Research Organization:
Ontario Cancer Inst., Toronto
OSTI ID:
5333911
Conference Information:
Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Journal Volume: 5:9
Country of Publication:
United States
Language:
English

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Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
560152 -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
ALKYLATING AGENTS
AMINES
ANIMALS
ANOXIA
ANTIMITOTIC DRUGS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CESIUM 137
CESIUM ISOTOPES
DATA
DATA FORMS
DISEASES
DOSES
DRUGS
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
INFORMATION
IRRADIATION
ISOLATED VALUES
ISOTOPES
MAMMALS
MICE
NEOPLASMS
NITROGEN MUSTARD
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
RADIATION DOSES
RADIATION EFFECTS
RADIOISOTOPES
RADIOSENSITIVITY EFFECTS
RESPONSE MODIFYING FACTORS
RODENTS
SARCOMAS
SURVIVAL CURVES
TIME DEPENDENCE
VERTEBRATES
WHOLE-BODY IRRADIATION
YEARS LIVING RADIOISOTOPES