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Regional bronchoconstriction in asthma. /sup 133/Xenon washout scans following parenteral methacholine

Journal Article · · Chest (Chicago); (United States)
OSTI ID:7215273
; ; ;

To determine the influence of bronchoconstriction on the distribution of ventilation during an asthma attack, pulmonary clearance of 133 xenon was evaluated in four normal and eight asthmatic subjects within three to five minutes after intramuscular injection of methacholine. In asthmatics, administration of 4-10 mg methacholine resulted in a decrease of forced vital capacity of 28.5 +- 5.1 (SE) percent and a decrease in expiratory flow at 60 percent vital capacity of 44.2 +- 6.9 percent (P less than 0.001). The cumulative ventilation required to reach 50 percent of the pre-washout radioactivity increased from 3.6 +- 0.8 to 9.9 +- 1.6 L after administration of the drug (P less than 0.05). The normal subjects showed no ventilatory effects after receiving 10 mg methacholine. Comparison of clearance of 133 xenon from ten areas of lung (each representing approximately 6 percent of the surface area of one lung) showed that all areas were affected to approximately the same extent during drug-induced asthma. These findings suggest that parenteral methacholine is an effective way to demonstrate airway hyperreactivity and that the airway response to methacholine in asthmatics is relatively generalized throughout the lung.

Research Organization:
Coll. of Medicine and Dentistry of New Jersey, Piscataway
OSTI ID:
7215273
Journal Information:
Chest (Chicago); (United States), Journal Name: Chest (Chicago); (United States) Vol. 70:6; ISSN CHETB
Country of Publication:
United States
Language:
English

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Related Subjects

560171* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Man-- (-1987)
560306 -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
BRONCHI
CLEARANCE
DAYS LIVING RADIOISOTOPES
DISEASES
EVEN-ODD NUCLEI
EXCRETION
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LUNG CLEARANCE
LUNGS
NUCLEI
ORGANIC COMPOUNDS
ORGANS
PHYSIOLOGY
RADIOISOTOPES
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
XENON 133
XENON ISOTOPES