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Airway reactivity and obstruction: relationship to pollutant induced bronchoconstriction in asthmatics

Conference · · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
OSTI ID:7022204
;

The authors have observed broad individual variations in the pulmonary function responses of mild, methacholine sensitive asthmatics exposed to the common air pollutants, sulfur dioxide (SO/sub 2/, n=27), nitrogen dioxide (NO/sub 2/, n=13) and ozone (O/sub 3/, n=21). The purpose of this study was to determine if variables which are indicative of airway reactivity (MS, methacholine sensitivity; EIB, exercise induced bronchoconstriction) or airway obstruction (BSRAW, baseline specific airway resistance; FEV1/FVC, ratio of forced expiratory volume in 1 sec to forced vital capacity) were related to pollutant induced responses of SRaw and FVC. SRaw and FVC responses were defined as the difference between pre and post pollutant exposure corrected for the difference between pre and post clean air exposure. Pearson product moment analysis was used to determine correlation coefficients (r). The most significant single variable related to the response of SRaw was BSRaw for SO/sub 2/ (r = 0.55, p = 0.003) and NO/sub 2/ (r = 0.79, p = 0.001), and FEV1/FVC for O/sub 3/ (r = -0.47, p = 0.03). No significant relationships occurred for the response of FVC. They conclude that baseline airway obstruction accounts for much of the variance in bronchoconstriction experienced by asthmatics exposed to air pollutants; it does not account for changes in lung volume.

Research Organization:
HERL-USEPA, Chapel Hill, NC
OSTI ID:
7022204
Report Number(s):
CONF-8604222-
Journal Information:
Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Vol. 45:4; ISSN FEPRA
Country of Publication:
United States
Language:
English

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Related Subjects

550900 -- Pathology
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ASTHMA
BIOLOGICAL VARIABILITY
BRONCHI
CHALCOGENIDES
DISEASES
EXERCISE
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
OXIDES
OXYGEN COMPOUNDS
OZONE
PATHOGENESIS
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
SULFUR COMPOUNDS
SULFUR DIOXIDE
SULFUR OXIDES
TOXICITY
VASOCONSTRICTION